It is suggested that prior to departing for a boat trip on the Muskingum River, boaters contact the park office to check on river and lock conditions. Boats with unlimited horsepower motors, house boats, pontoon boats, canoes and rowboats travel the river. Public launch ramps are provided at Locks 4, 5, 6 and 11. Private ramps are located near Locks 2, 7 and 10.

The Muskingum River is navigable from Dresden to Marietta. However, the river channel from Dresden to Ellis is unmarked and difficult to follow. Information on navigation charts can be obtained at the parkway office.

Some of the tributaries which empty into the Muskingum River are also navigable for short distances and provide excellent fishing. The Licking River which joins the Muskingum River in Zanesville, is navigable only by canoe or rowboat.

All three species of black bass (largemouth, smallmouth and spotted), saugeye and various species of catfish are taken from the river. Bass are also found in several tributaries. Fishing is permitted from boats and at each of the lock sites; however, fishing is prohibited from the lock walls. A valid Ohio fishing license is required.